Sisco began his professional baseball career with the Chicago Cubs’ Arizona Rookie League team in 2001. He was at one time a highly-regarded Cubs prospect, but his star gradually fell and he ended up being picked by Kansas City in the 2004 Rule V draft. Sisco spent the 2005 and 2006 seasons with the Royals, going 3-8 with a 4.87 ERA in 132 relief appearances. He was dealt to the Chicago White Sox and went 0-1 with a 8.39 ERA in 18 trips from the bullpen before being released after the 2007 season. Sisco missed the 2008 campaign after undergoing Tommy John surgery before pitching for the Athletics and Giants organizations the past two years.
Sisco gained notoriety his first time south of the border while with Mazatlan in 2006 when a team official spotted him munching a taco in the ballpark concourse during the first inning of a ballgame. Sisco was released the next day…after tossing six innings of two-run ball.